INFECTION AS ETIOLOGY OF SPONGIFORM ENCEPHALOPATHY (CREUTZFELDT-JAKOB DISEASE)

被引：154

作者：

GIBBS, CJ

GAJDUSEK, DC

机构：

[1] National Institute of Neurological Diseases and Stroke, Bethesda

来源：

SCIENCE | 1969年 / 165卷 / 3897期

关键词：

D O I：

10.1126/science.165.3897.1023

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Fatal spongiform encephalopathy occurred in four chimpanzees 12 to 14 months after inoculation with suspensions of brain from four patients, respectively. Chimpanzee to chimpanzee transmission was effected without reduction in incubation period. Retransmission of the disease to a second chimpanzee occurred when an inoculum that had been stored at -70°C for over 2 years was used.

引用

页码：1023 / &

共 6 条

[1]

BECK E, IN PRESS

[2] EXPERIMENTAL TRANSMISSION OF A KURU-LIKE SYNDROME TO CHIMPANZEES [J].