HUMAN TUMOR-NECROSIS-FACTOR-ALPHA AUGMENTS EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS IN RATS

被引：116

作者：

KURODA, Y ^{[1
]}

SHIMAMOTO, Y ^{[1
]}

机构：

[1] SAGA MED SCH,DEPT INTERNAL MED,HEMATOL SECT,SAGA 849,JAPAN

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1991年 / 34卷 / 2-3期

关键词：

TUMOR NECROSIS FACTOR-ALPHA; HUMAN RECOMBINANT TUMOR NECROSIS FACTOR-ALPHA; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; (LEWIS RAT);

D O I：

10.1016/0165-5728(91)90125-Q

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The effect of human recombinant tumor necrosis factor-alpha (TNF) on experimental allergic encephalomyelitis (EAE) was studied in Lewis rats. TNF was injected intraperitoneally at a daily dose of 1 X 10(3) or 2 X 10(4) U for 8 consecutive days from one day after sensitization with guinea-pig spinal cord in complete Freund's adjuvant. All rats in the control group developed clinical signs of EAE but recovered within 8 days after the onset. Injections of 2 X 10(4) U/day of TNF resulted in a significant prolongation of clinical EAE: clinical signs were sustained for up to 15 days after onset. Histologically, rats receiving 2 X 10(4) U/day of TNF had more severe cellular infiltrations in the spinal cord than controls. The augmentation of EAE was not found in rats receiving 1 X 10(3) U/day of TNF or TNF that had been neutralized with anti-TNF monoclonal antibody.

引用

页码：159 / 164

页数：6

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