A CHEMICAL-SCREENING STRATEGY FOR THE DEREPLICATION AND PRIORITIZATION OF HIV-INHIBITORY AQUEOUS NATURAL-PRODUCTS EXTRACTS

被引：78

作者：

CARDELLINA, JH ^{[1
]}

MUNRO, MHG ^{[1
]}

FULLER, RW ^{[1
]}

MANFREDI, KP ^{[1
]}

MCKEE, TC ^{[1
]}

TISCHLER, M ^{[1
]}

BOKESCH, HR ^{[1
]}

GUSTAFSON, KR ^{[1
]}

BEUTLER, JA ^{[1
]}

BOYD, MR ^{[1
]}

机构：

[1] NATL CANC INST,DIV CANC,DEV THERAPEUT PROGRAM,DRUG DISCOVERY RES & DEV LAB,BLDG 1052,ROOM 121,FREDERICK,MD 21702

来源：

JOURNAL OF NATURAL PRODUCTS | 1993年 / 56卷 / 07期

关键词：

D O I：

10.1021/np50097a016

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A relatively high percentage (ca. 15 %) of aqueous extracts from terrestrial plants, cyanobacteria, and marine invertebrates and algae has exhibited activity in the National Cancer Institute's primary AIDS-antiviral screen. By removal of anionic polysaccharides in a first stage of dereplication, we have eliminated from further consideration a considerable number of these extracts. However, a still substantial proportion of the active extracts remained, from which we wished to select and prioritize a small percentage for our detailed bioassay-directed fractionation studies. Therefore, a chemical screening protocol, utilizing various solid-phase extraction cartridges, has been developed for a second-stage dereplication and to assist in prioritization of these extracts for our further investigations.

引用

页码：1123 / 1129

页数：7

共 20 条

[1] PRESENCE OF SULFATED GLYCANS IN ASCIDIAN TUNIC AND IN THE BODY WALL OF A SEA-CUCUMBER [J].