REGULATED IMPORT AND DEGRADATION OF A CYTOSOLIC PROTEIN IN THE YEAST VACUOLE

被引：139

作者：

CHIANG, HL

SCHEKMAN, R

机构：

[1] Division of Biochemistry and Molecular Biology, Howard Hughes Medical Institute, University of California at Berkeley, Berkeley

来源：

NATURE | 1991年 / 350卷 / 6316期

关键词：

D O I：

10.1038/350313a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The key regulatory enzyme in gluconeogenesis, fructose 1,6-bisphosphatase (FBPase) is subject to glucose-stimulated proteolytic degradation in Saccharomyces cerevisiae. This process involves the regulated transfer of FBPase directly from the cytosol into the vacuole or a vacuole-related organelle. Glucose may regulate the production of an FBPase receptor or import factor that is transported to the vacuole through the secretory pathway.

引用

页码：313 / 318

页数：6

共 32 条

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