SIGNAL TRANSDUCTION FROM CELL-SURFACE TO NUCLEUS IN DEVELOPMENT AND DISEASE

被引：256

作者：

KARIN, M

机构：

[1] Department of Pharmacology, School of Medicine, University of California, La Jolla

来源：

FASEB JOURNAL | 1992年 / 6卷 / 08期

关键词：

SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR; PROTEIN PHOSPHORYLATION;

D O I：

10.1096/fasebj.6.8.1317309

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent studies indicate that extracellular signals affect cell proliferation and differentiation by modulating transcription factor activity via protein phosphorylation cascades. This review discusses the basic outline of the eukaryotic signal transduction systems used to transmit information from the cell surface to the transcriptional machinery in the nucleus. Several examples that illustrate how these pathways control cell proliferation, differentiation and development are discussed.

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页码：2581 / 2590

页数：10

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