BIOACCUMULATION OF WATER-SOLUBLE ALUMINUM-CHLORIDE IN THE HIPPOCAMPUS AFTER TRANSDERMAL UPTAKE IN MICE

被引:36
作者
ANANE, R
BONINI, M
GRAFEILLE, JM
CREPPY, EE
机构
[1] UNIV BORDEAUX 2, UNITE FORMAT & RECH PHARM, TOXICOL & HYG APPL LAB, F-33000 BORDEAUX, FRANCE
[2] SOC ETUD & RECH MICROANAL, F-33600 PESSAC, FRANCE
关键词
ALUMINUM CHLORIDE (ALCL3,6H(2)O); TRANSCUTANEOUS ABSORPTION; BIOACCUMULATION; HIPPOCAMPUS; MOUSE;
D O I
10.1007/s002040050214
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
Normally, only very small amounts of ingested aluminium are absorbed and accumulated. Despite the percutaneous absorption of many drugs and chemicals, the skin has not been considered as a possible site at which aluminium could enter the body. Application of low aqueous concentrations of aluminium chloride (AlCl3,6H(2)O) (0.025-0.1 mu g/cm(2)) to healthy shaved Swiss mouse skin for 130 days led to a significant increase in urine, serum and whole brain aluminium, especially in the hippocampus, compared to control animals. This percutaneous uptake and accumulation of aluminium in the brain was greater than that caused by dietary exposure to 2.3 mu g per day in feed and water. In vitro studies demonstrated the passage of aluminium through viable mouse skin. This study shows for the first time that aluminium is absorbed through the skin of mice in vivo and this contributes to a greater body burden than does oral uptake.
引用
收藏
页码:568 / 571
页数:4
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