PROTON MAGNETIC-RESONANCE SPECTROSCOPIC IMAGES AND MRI VOLUMETRIC STUDIES FOR LATERALIZATION OF TEMPORAL-LOBE EPILEPSY

被引：40

作者：

CENDES, F ^{[1
]}

ANDERMANN, F ^{[1
]}

DUBEAU, F ^{[1
]}

ARNOLD, DL ^{[1
]}

机构：

[1] MONTREAL NEUROL HOSP & INST,MONTREAL,PQ H3A 2B4,CANADA

来源：

MAGNETIC RESONANCE IMAGING | 1995年 / 13卷 / 08期

基金：

英国医学研究理事会;

关键词：

NUCLEAR MAGNETIC RESONANCE; SPECTROSCOPY; N-ACETYLASPARTATE; MRI; VOLUMETRIC MEASUREMENTS; AMYGDALA; HIPPOCAMPUS; EEG;

D O I：

10.1016/0730-725X(95)02031-N

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

We obtained 2D magnetic resonance (MR) spectroscopic images (MRSI) and MRI volumetric measurements (MRIV) of amygdala and hippocampus in 30 consecutive patients with temporal lobe epilepsy (TLE) being evaluated for surgical treatment. Both MRSI and MRIV lateralization showed good agreement with the current gold standard of clinical-ETC lateralization. Each exam separately correctly lateralized 25 out of 30 patients with no false lateralization. Combining both exams, lateralization could be achieved in 28 out of 30 patients. The two patients with no significant asymmetry had bitemporal EEG abnormalities, and bilateral damage on both MRIV and MRSI. There was a good correlation between the magnitude of the MRSI and MRIV asymmetry (Pearson coefficient = 0.83; p <.0001). Both MRSI and MRIV were normal in our patients with seizures originating outside the temporal lobes. Both MRIV and MRSI can lateralize TLE in 83% of patients. Combination of the two modalities allows lateralization in 93% of patients. Patients who cannot be lateralized generally have symmetrical bitemporal abnormalities; they are not incorrectly lateralized. The structural and chemical pathologic abnormalities seen in TLE seem to be associated with the seizure focus, and may be as, or even more, reliable than a few recorded seizures in predicting the side from which most seizures originate.

引用

页码：1187 / 1191

页数：5

共 24 条

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