IDENTIFYING SMALL-MOLECULE LEAD COMPOUNDS - THE SCREENING APPROACH TO DRUG DISCOVERY

被引：64

作者：

BEVAN, P

RYDER, H

SHAW, A

机构：

[1] Xenova Ltd, Slough, Berkshire SL1 4EF

来源：

TRENDS IN BIOTECHNOLOGY | 1995年 / 13卷 / 03期

关键词：

D O I：

10.1016/S0167-7799(00)88916-7

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A number of new technologies that enable high-throughput, cost-effective screening of potential drug candidates have been developed in recent years. Such compounds may be derived from the large proprietary collections held by pharmaceutical companies, from new synthetic approaches such as combinatorial chemistry, or from natural sources. The latter remain a major source of new chemicals: many are already used in human treatment and many others are currently undergoing evaluation as the potential medicines of the future.

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页码：115 / 121

页数：7

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