EFFECTIVE TUMOR VACCINE GENERATED BY FUSION OF HEPATOMA-CELLS WITH ACTIVATED B-CELLS

被引：143

作者：

GUO, YJ ^{[1
]}

WU, MC ^{[1
]}

CHEN, H ^{[1
]}

WANG, XN ^{[1
]}

LIU, GL ^{[1
]}

LI, GL ^{[1
]}

MA, J ^{[1
]}

SY, MS ^{[1
]}

机构：

[1] CASE WESTERN RESERVE UNIV,INST PATHOL,CLEVELAND,OH 44106

来源：

SCIENCE | 1994年 / 263卷 / 5146期

关键词：

D O I：

10.1126/science.7507262

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Fusion of BERH-2 rat hepatocellular carcinoma cells with activated B cells produced hybrid cells that lost their tumorigenicity and became immunogenic. Syngeneic rats injected with BERH-2-B hybrid cells became resistant to challenge with parental BERH-2 cells, and rats with established BERH-2 hepatomas were cured by subsequent injection of BERH-2-B cells. Both CD4+ and CD8+ cells were essential for the induction of protective immunity; however, only CD8+ cells were required for the eradication of BERH-2 tumors. The generation of hybrid tumor cells that elicit antitumor immune responses may be a useful strategy for cancer immunotherapy.

引用

页码：518 / 520

页数：3

共 18 条

[1]

ALAN J, 1988, IMMUNOCHEMISTRY PRAC, pCH2

[2] TUMOR SUPPRESSION AFTER TUMOR-CELL TARGETED TUMOR-NECROSIS-FACTOR-ALPHA GENE-TRANSFER [J].

BLANKENSTEIN, T ;

QIN, ZH ;

UBERLA, K ;

MULLER, W ;

ROSEN, H ;

VOLK, HD ;

DIAMANTSTEIN, T .

JOURNAL OF EXPERIMENTAL MEDICINE, 1991, 173 (05) :1047-1052

[3] COSTIMULATION OF ANTITUMOR IMMUNITY BY THE B7 COUNTERRECEPTOR FOR THE LYMPHOCYTE-T MOLECULES CD28 AND CTLA-4 [J].

CHEN, LP ;

ASHE, S ;

BRADY, WA ;

HELLSTROM, I ;

HELLSTROM, KE ;

LEDBETTER, JA ;

MCGOWAN, P ;

LINSLEY, PS .

CELL, 1992, 71 (07) :1093-1102

[4]

CHESTNUT RW, 1981, J IMMUNOL, V128, P1075

[5]

ELIOT BE, 1989, ADV CANCER RES, V53, P181

[6] INTERLEUKIN-2 PRODUCTION BY TUMOR-CELLS BYPASSES T-HELPER FUNCTION IN THE GENERATION OF AN ANTITUMOR RESPONSE [J].

FEARON, ER ;

PARDOLL, DM ;

ITAYA, T ;

GOLUMBEK, P ;

LEVITSKY, HI ;

SIMONS, JW ;

KARASUYAMA, H ;

VOGELSTEIN, B ;

FROST, P .

CELL, 1990, 60 (03) :397-403

[7]

GEORGE JT, 1993, CANCER RES, V53, P2374

[8]

Guo Y., UNPUB

[9]

GUO YJ, 1988, J MIL MED COLL PEOPL, V3, P272

[10] RECEPTOR-MEDIATED ANTIGEN UPTAKE AND ITS EFFECT ON ANTIGEN PRESENTATION TO CLASS-II-RESTRICTED LYMPHOCYTES-T [J].

LANZAVECCHIA, A .

ANNUAL REVIEW OF IMMUNOLOGY, 1990, 8 :773-793

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