OCCURRENCE OF BETA-2-MICROGLOBULIN IN MAMMALIAN LYMPHOCYTES AND ERYTHROCYTES

被引：15

作者：

BJORCK, L

AKERSTROM, B

BERGGARD, I

机构：

[1] Department of Physiological Chemistry, University of Lund, Lund

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1979年 / 9卷 / 06期

关键词：

D O I：

10.1002/eji.1830090613

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cell‐associated β2‐microglobulin (β2m) has been studied by quantitative techniques in lymphocytes and erythrocytes of guinea pig, rabbit, rat and man. β2m was solubilized by sonication followed by treatment with acid, deoxycholate or thiocyanate, and then determined by radioimmunoassay. The average number of β2m molecules per lymphocyte, estimated after acidification, varied between 0.89 × 105 and 7.1 × 105. Rat erythrocytes contained 3.0 × 103 molecules per cell, whereas no β2m was detected in red blood cells from the three other species. A relatively large part of β2m in the mammalian lymphocytes and in rat erythrocytes was present on the cell surface according to a radioimmunoassay procedure using anti‐β2m antisera that had been absorbed with the blood cells analyzed. Copyright © 1979 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim

引用

页码：486 / 490

页数：5

共 30 条

[1]

BERGGARD I, 1968, J BIOL CHEM, V243, P4095

[2] ISOLATION AND CHARACTERISTICS OF A RABBIT BETA-2-MICROGLOBULIN - COMPARISON WITH HUMAN BETA-2-MICROGLOBULIN [J].