THIOREDOXIN STRUCTURE AND MECHANISM - CONFORMATIONAL-CHANGES ON OXIDATION OF THE ACTIVE-SITE SULFHYDRYLS TO A DISULFIDE

被引：374

作者：

HOLMGREN, A

机构：

[1] Arne Holmgren, Medical Nobel Institute for Biochemistry, Department of Medical Biochemistry and Biophysics

来源：

STRUCTURE | 1995年 / 3卷 / 03期

关键词：

D O I：

10.1016/S0969-2126(01)00153-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The recent high-resolution solution structures of human and Escherichia coli thioredoxin in their oxidized and reduced states support a catalytic model of protein disulfide reduction involving binding of a target protein and nucleophilic attack by the active-site Cys32 thiolate to form a transition state mixed disulfide. © 1995 Elsevier Science Ltd. All rights reserved.

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页码：239 / 243

页数：5

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共 32 条

[1] REGULATION OF CO2 ASSIMILATION IN OXYGENIC PHOTOSYNTHESIS - THE FERREDOXIN THIOREDOXIN SYSTEM - PERSPECTIVE ON ITS DISCOVERY, PRESENT STATUS, AND FUTURE-DEVELOPMENT [J].

BUCHANAN, BB .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1991, 288 (01) :1-9

[2] THE NUCLEAR-MAGNETIC-RESONANCE SOLUTION STRUCTURE OF THE MIXED DISULFIDE BETWEEN ESCHERICHIA-COLI GLUTAREDOXIN(C14S) AND GLUTATHIONE [J].

BUSHWELLER, JH ;

BILLETER, M ;

HOLMGREN, A ;

WUTHRICH, K .

JOURNAL OF MOLECULAR BIOLOGY, 1994, 235 (05) :1585-1597

[3] PROTON-TRANSFER EFFECTS IN THE ACTIVE-SITE REGION OF ESCHERICHIA-COLI THIOREDOXIN USING 2-DIMENSIONAL H-1-NMR [J].

DYSON, HJ ;

TENNANT, LL ;

HOLMGREN, A .

BIOCHEMISTRY, 1991, 30 (17) :4262-4268

[4] ASSIGNMENT OF THE PROTON NMR-SPECTRUM OF REDUCED AND OXIDIZED THIOREDOXIN - SEQUENCE-SPECIFIC ASSIGNMENTS, SECONDARY STRUCTURE, AND GLOBAL FOLD [J].

DYSON, HJ ;

HOLMGREN, A ;

WRIGHT, PE .

BIOCHEMISTRY, 1989, 28 (17) :7074-7087

[5] CONFORMATIONAL AND FUNCTIONAL SIMILARITIES BETWEEN GLUTAREDOXIN AND THIOREDOXINS [J].

EKLUND, H ;

CAMBILLAU, C ;

SJOBERG, BM ;

HOLMGREN, A ;

JORNVALL, H ;

HOOG, JO ;

BRANDEN, CI .

EMBO JOURNAL, 1984, 3 (07) :1443-1449

[6] STRUCTURAL AND FUNCTIONAL RELATIONS AMONG THIOREDOXINS OF DIFFERENT SPECIES [J].

EKLUND, H ;

GLEASON, FK ;

HOLMGREN, A .

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 1991, 11 (01) :13-28

[7] 1H AND N-15 RESONANCE ASSIGNMENTS AND SECONDARY STRUCTURE OF THE HUMAN THIOREDOXIN C62A, C69A, C73A MUTANT [J].

FORMANKAY, JD ;

CLORE, GM ;

STAHL, SJ ;

GRONENBORN, AM .

JOURNAL OF BIOMOLECULAR NMR, 1992, 2 (05) :431-445

[8] HIGH-RESOLUTION 3-DIMENSIONAL STRUCTURE OF REDUCED RECOMBINANT HUMAN THIOREDOXIN IN SOLUTION [J].

FORMANKAY, JD ;

CLORE, GM ;

WINGFIELD, PT ;

GRONENBORN, AM .

BIOCHEMISTRY, 1991, 30 (10) :2685-2698

[9] RELATIONSHIP BETWEEN ELECTROSTATICS AND REDOX FUNCTION IN HUMAN THIOREDOXIN - CHARACTERIZATION OF PH TITRATION SHIFTS USING 2-DIMENSIONAL HOMONUCLEAR AND HETERONUCLEAR NMR [J].

FORMANKAY, JD ;

CLORE, GM ;

GRONENBORN, AM .

BIOCHEMISTRY, 1992, 31 (13) :3442-3452

[10] THE ROLE OF THE ALPHA-HELIX DIPOLE IN PROTEIN FUNCTION AND STRUCTURE [J].

HOL, WGJ .

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 1985, 45 (03) :149-195

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