ENHANCED PROTEIN THERMOSTABILITY FROM DESIGNED MUTATIONS THAT INTERACT WITH ALPHA-HELIX DIPOLES

被引：291

作者：

NICHOLSON, H

BECKTEL, WJ

MATTHEWS, BW

机构：

[1] UNIV OREGON,DEPT PHYS,EUGENE,OR 97403

[2] UNIV OREGON,DEPT CHEM,EUGENE,OR 97403

来源：

NATURE | 1988年 / 336卷 / 6200期

关键词：

D O I：

10.1038/336651a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

引用

页码：651 / 656

页数：6

共 47 条

[1] REPLACEMENTS OF PRO86 IN PHAGE-T4 LYSOZYME EXTEND AN ALPHA-HELIX BUT DO NOT ALTER PROTEIN STABILITY [J].

ALBER, T ;

BELL, JA ;

DAOPIN, S ;

NICHOLSON, H ;

WOZNIAK, JA ;

COOK, S ;

MATTHEWS, BW .

SCIENCE, 1988, 239 (4840) :631-635

[2]

ALBER T, 1987, METHOD ENZYMOL, V154, P511

[3] A GENETIC SCREEN FOR MUTATIONS THAT INCREASE THE THERMAL-STABILITY OF PHAGE-T4 LYSOZYME [J].

ALBER, T ;

WOZNIAK, JA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (03) :747-750

[4] CONTRIBUTIONS OF HYDROGEN-BONDS OF THR-157 TO THE THERMODYNAMIC STABILITY OF PHAGE-T4 LYSOZYME [J].

ALBER, T ;

SUN, DP ;

WILSON, K ;

WOZNIAK, JA ;

COOK, SP ;

MATTHEWS, BW .

NATURE, 1987, 330 (6143) :41-46

[5]

ALBER T, 1986, PROTEIN STRUCTURE FO, P307

[6]

BAASE WA, 1986, BIOPHYS J, V49, pA109

[7] HYDROGEN-BONDING IN GLOBULAR-PROTEINS [J].

BAKER, EN ;

HUBBARD, RE .

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 1984, 44 (02) :97-179

[8] PROTEIN STABILITY CURVES [J].

BECKTEL, WJ ;

SCHELLMAN, JA .

BIOPOLYMERS, 1987, 26 (11) :1859-1877

[9] THERMAL-DENATURATION OF BACTERIOPHAGE-T4 LYSOZYME AT NEUTRAL PH [J].

BECKTEL, WJ ;

BAASE, WA .

BIOPOLYMERS, 1987, 26 (05) :619-623

[10] MECHANISMS OF PROTEIN AND POLYPEPTIDE HELIX INITIATION [J].

BLAGDON, DE ;

GOODMAN, M .

BIOPOLYMERS, 1975, 14 (01) :241-245

← 1 2 3 4 5 →