POLY(ADP-RIBOSE) POLYMERASE - A MOLECULAR NICK-SENSOR

被引：741

作者：

DEMURCIA, G

DEMURCIA, JM

机构：

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1994年 / 19卷 / 04期

关键词：

D O I：

10.1016/0968-0004(94)90280-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Poly(ADP-ribose) polymerase (PARP) participates in the intricate network of systems developed by the eukaryotic cell to cope with the numerous environmental and endogenous genotoxic agents. Cloning of the PARP gene has allowed the development of genetic and molecular approaches to elucidate the structure and function of this abundant and highly conserved enzyme.

引用

页码：172 / 176

页数：5

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