PREVENTION OF COLLAGEN-INDUCED ARTHRITIS WITH AN ANTIBODY TO GP39, THE LIGAND FOR CD40

被引：445

作者：

DURIE, FH

FAVA, RA

FOY, TM

ARUFFO, A

LEDBETTER, JA

NOELLE, RJ

机构：

[1] DARTMOUTH COLL,SCH MED,DEPT MICROBIOL,LEBANON,NH 03756

[2] DEPT VET ADM MED CTR,WHITE RIVER JCT,VT 05009

[3] BRISTOL MYERS SQUIBB PHARMACEUT RES INST,SEATTLE,WA 98121

[4] DARTMOUTH COLL,SCH MED,DEPT MED,WHITE RIVER JCT,VT 05009

来源：

SCIENCE | 1993年 / 261卷 / 5126期

关键词：

D O I：

10.1126/science.7689748

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The ligand for the CD40 antigen is a 39-kilodalton protein, gp39, expressed on the surface of activated CD4+ T cells and is essential for thymus-dependent humoral immunity. The role of gp39-CD40 interactions in autoimmune disease was investigated in vivo with the use of an antibody that blocks their interactions (anti-gp39). Arthritis induced in mice by immunization with type II collagen was inhibited by anti-gp39. Anti-gp39 blocked the development of joint inflammation, serum antibody titers to collagen, the infiltration of inflammatory cells into the subsynovial tissue, and the erosion of cartilage and bone. Thus, interference with gp39-CD40 interactions may have therapeutic potential in the treatment of autoimmune disease.

引用

页码：1328 / 1330

页数：3

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