MOLECULAR-CLONING OF A NOVEL-G PROTEIN-COUPLED RECEPTOR THAT MAY BELONG TO THE NEUROPEPTIDE RECEPTOR FAMILY

被引：211

作者：

EVA, C ^{[1
]}

KEINANEN, K ^{[1
]}

MONYER, H ^{[1
]}

SEEBURG, P ^{[1
]}

SPRENGEL, R ^{[1
]}

机构：

[1] UNIV HEIDELBERG,ZENTRUM MOLEK BIOL,W-6900 HEIDELBERG,GERMANY

来源：

FEBS LETTERS | 1990年 / 271卷 / 1-2期

关键词：

G protein receptor; Neuropeptide receptor; Tachykinin receptor;

D O I：

10.1016/0014-5793(90)80377-U

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel cDNA encoding a putative G protein-coupled receptor was isolated from a rat forebrain cDNA library by homology screening. Sequence comparison demonstrates that the encoded polypeptide containing seven transmembrane domains shows highest homology with tachykinin receptors, particularly in the transmembrane domains and the first intracellular loop. The mRNA for this new receptor seems specifically expressed in brain and is prominently localized in specific nuclei of the rat brain, including thalamus, cerebral cortex and hippocampus. We speculate that a neuropeptide may be the natural ligand of this novel G protein-coupled receptor. © 1990.

引用

页码：81 / 84

页数：4

共 14 条

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