MONOCLONAL ANTIBODIES IN CELL-MEDIATED CYTOTOXICITY AGAINST HUMAN-MELANOMA AND COLORECTAL-CARCINOMA

被引：157

作者：

HERLYN, D ^{[1
]}

HERLYN, M ^{[1
]}

STEPLEWSKI, Z ^{[1
]}

KOPROWSKI, H ^{[1
]}

机构：

[1] WISTAR INST ANAT & BIOL, 36TH ST SPRUCE, PHILADELPHIA, PA 19104 USA

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1979年 / 9卷 / 08期

关键词：

D O I：

10.1002/eji.1830090817

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Hybridoma‐derived monoclonal anti‐melanoma antibodies and anti‐colorectal carcinoma antibodies were found to mediate in vitro antibody‐dependent cell‐mediated cytotoxicity (ADCC) reactions against melanoma and colorectal carcinoma cells, respectively. The antigen(s) detected in ADCC on melanoma cells maintained for more than one hundred passages in tissue culture were also found on two recently established melanoma cell lines. These antigens were not detected on skin fibroblasts of the same patients from whom the melanomas were obtained. The ADCC reactivities of anti‐melanoma and anti‐colorectal carcinoma antibodies were found to be specific for melanoma cells and colorectal carcinoma cells, respectively. Copyright © 1979 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim

引用

页码：657 / 659

页数：3

共 8 条

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