MULTIPLICITY GENERATES DIVERSITY IN THE RETINOIC ACID SIGNALING PATHWAYS

被引：868

作者：

LEID, M

KASTNER, P

CHAMBON, P

机构：

[1] Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, U/184 de Biologie Moléculaire et de Génie Génétique de I'INSERM, Institut de Chimie Biologique, Faculté de Médecine

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1992年 / 17卷 / 10期

关键词：

D O I：

10.1016/0968-0004(92)90014-Z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Complexity in the retinoid signalling system arises from a combination of several forms of retinoic acid, multiple cytoplasmic binding proteins and nuclear receptors, and the existence of polymorphic retinoic acid response elements. Additional diversity appears to be generated by heterodimeric interactions between two families of nuclear retinoic acid receptors, and between nuclear retinoic acid receptors and other members of the nuclear receptor superfamily. Thus, a complex array of combinatorial effects is beginning to emerge which may account for the pleiotropic effects of retinoids.

引用

页码：427 / 433

页数：7

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