LOCALIZATION OF THE MOUSE THYMIDINE KINASE GENE TO THE DISTAL PORTION OF CHROMOSOME-11

被引：23

作者：

HOZIER, J

SCALZI, J

SAWYER, J

CARLEY, N

APPLEGATE, M

CLIVE, D

MOORE, MM

机构：

[1] APPL GENET LABS INC,MELBOURNE,FL 32091

[2] BURROUGHS WELLCOME CO,DIV PATHOL & TOXICOL,RES TRIANGLE PK,NC 27709

[3] US EPA,HLTH EFFECTS RES LAB,DIV GENET TOXICOL,RES TRIANGLE PK,NC 27711

来源：

GENOMICS | 1991年 / 10卷 / 03期

关键词：

D O I：

10.1016/0888-7543(91)90469-U

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We report the cytogenetic mapping of the thymidine kinase (tk-1) gene in the mouse using two complementary and independent analyses: (1) investigation of chromosome aberrations associated with tk-1 gene inactivation in the L5178Y TK+/- -3.7.2C cell line, and (2) fluorescence in situ molecular hybridization of cloned tk-1 cDNA probes to mitotic chromosomes of this cell line. The consensus location from both analyses is 11E1-E2. Consideration of the mouse tk-1 gene localization, along with evidence that the homologous human TK1 gene is located distally on the large arm of chromosome 17, appears to extend the region of homology between MMU11 and HSA17 to the distal end of both chromsomes. © 1991.

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页码：827 / 830

页数：4

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