ADRENAL TYROSINE HYDROXYLASE - COMPENSATORY INCREASE IN ACTIVITY AFTER CHEMICAL SYMPATHECTOMY

被引：202

作者：

MUELLER, RA

THOENEN, H

AXELROD, J

机构：

[1] Laboratory of Clinical Science, National Institute of Mental Health, Bethesda

[2] Hoffmann-La Roche, Basel

来源：

SCIENCE | 1969年 / 163卷 / 3866期

关键词：

D O I：

10.1126/science.163.3866.468

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Destruction of peripheral sympathetic nerve endings with 6-hydroxydopamine causes a disappearance of cardiac tyrosine hydroxylase, accompanied by a twofold increase in adrenal tyrosine hydroxylase and a small increase in phenyl-ethanolamine-N-methyl transferase. No change in adrenal catecholamine content occurs under these conditions.

引用

页码：468 / &

共 12 条

[1]

ANTON AH, 1962, J PHARMACOL EXP THER, V138, P360

[2]

AXELROD J, 1962, J BIOL CHEM, V237, P1657

[3]

GEROLD M, PERSONAL COMMUNICATI

[4]

HAUSLER G, IN PRESS

[5] A NEW CLASS OF TYROSINE HYDROXYLASE INHIBITORS AND A SIMPLE ASSAY OF INHIBITION IN VIVO [J].