REGIONAL GLUCOSE METABOLIC CHANGES AFTER LEARNING A COMPLEX VISUOSPATIAL MOTOR TASK - A POSITRON EMISSION TOMOGRAPHIC STUDY

被引：321

作者：

HAIER, RJ

SIEGEL, BV

MACLACHLAN, A

SODERLING, E

LOTTENBERG, S

BUCHSBAUM, MS

机构：

[1] Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, CA

来源：

BRAIN RESEARCH | 1992年 / 570卷 / 1-2期

关键词：

LEARNING; INTELLIGENCE; FLUORODEOXYGLUCOSE; POSITRON EMISSION TOMOGRAPHY; GLUCOSE; BRAIN EFFICIENCY;

D O I：

10.1016/0006-8993(92)90573-R

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Regional cerebral glucose metabolic rate (GMR) quantified with positron emission tomography (PET) with 18-fluoro-2-deoxyglucose (FDG) was measured twice in 8 young men performing a complex visuospatial/motor task (the computer game Tetris), before and after practice. After 4-8 weeks of daily practice on Tetris, GMR in cortical surface regions decreased despite a more than 7-fold increase in performance. Subjects who improved their Tetris performance the most after practice showed the largest glucose metabolic decreases after practice in several areas. These results suggest that learning may result in decreased use of extraneous or inefficient brain areas. Changes in regional subcortical glucose metabolic rate with practice may reflect changes in cognitive strategy that are a part of the learning process.

引用

页码：134 / 143

页数：10

共 13 条

[1] POSITRON EMISSION TOMOGRAPHIC SCAN INVESTIGATIONS OF HUNTINGTONS-DISEASE - CEREBRAL METABOLIC CORRELATES OF COGNITIVE FUNCTION [J].

BERENT, S ;

GIORDANI, B ;

LEHTINEN, S ;

MARKEL, D ;

PENNEY, JB ;

BUCHTEL, HA ;

STAROSTARUBINSTEIN, S ;

HICHWA, R ;

YOUNG, AB .

ANNALS OF NEUROLOGY, 1988, 23 (06) :541-546

[2]

BUCHSBAUM MS, 1984, ARCH GEN PSYCHIAT, V41, P1159

[3] REGIONAL CEREBRAL GLUCOSE METABOLIC-RATE IN HUMAN SLEEP ASSESSED BY POSITRON EMISSION TOMOGRAPHY [J].

BUCHSBAUM, MS ;

GILLIN, JC ;

WU, J ;

HAZLETT, E ;

SICOTTE, N ;

DUPONT, RM ;

BUNNEY, WE .

LIFE SCIENCES, 1989, 45 (15) :1349-1356

[4] POSITRON EMISSION TOMOGRAPHY ASSESSMENT OF EFFECTS OF BENZODIAZEPINES ON REGIONAL GLUCOSE METABOLIC-RATE IN PATIENTS WITH ANXIETY DISORDER [J].

BUCHSBAUM, MS ;

WU, J ;

HAIER, R ;

HAZLETT, E ;

BALL, R ;

KATZ, M ;

SOKOLSKI, K ;

LAGUNASSOLAR, M ;

LANGER, D .

LIFE SCIENCES, 1987, 40 (25) :2393-2400

[5]

DIXON WJ, 1982, BMDP BIOMEDICAL COMP

[6] CORTICAL GLUCOSE METABOLIC-RATE CORRELATES OF ABSTRACT REASONING AND ATTENTION STUDIED WITH POSITRON EMISSION TOMOGRAPHY [J].

HAIER, RJ ;

SIEGEL, BV ;

NUECHTERLEIN, KH ;

HAZLETT, E ;

WU, JC ;

PAEK, J ;

BROWNING, HL ;

BUCHSBAUM, MS .

INTELLIGENCE, 1988, 12 (02) :199-217

[7]

HAIER RJ, UNPUB BRAIN EFFICIEN

[8]

MATSUI T, 1978, ATLAS HUMAN BRAIN CO

[9]

NEUCHTERLEIN KH, 1983, SCIENCE, V220, P327

[10]

Parks R W, 1989, J Neuropsychiatry Clin Neurosci, V1, P269

← 1 2 →