MAINTENANCE OF INVIVO TOLERANCE BY PERSISTENCE OF ANTIGEN

被引：208

作者：

RAMSDELL, F ^{[1
]}

FOWLKES, BJ ^{[1
]}

机构：

[1] NIAID,CELLULAR & MOLEC IMMUNOL LAB,BETHESDA,MD 20892

来源：

SCIENCE | 1992年 / 257卷 / 5073期

关键词：

D O I：

10.1126/science.257.5073.1130

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

T cells of the immune system respond only to foreign antigens because those cells with reactivity for self proteins are either deleted during their development or rendered nonresponsive (anergic). The maintenance of the nonresponsive state was found to require the continual exposure of the anergic T cells to antigen. When anergic T cells were removed from the self antigen by adoptive transfer to a mouse strain lacking the antigen or by in vitro culture, nonresponsiveness was reversed and the anergic cells returned to normal functional status.

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页码：1130 / 1134

页数：5

相关论文

共 30 条

[1] ANTI-CD4 MEDIATES CLONAL ANERGY DURING TRANSPLANTATION TOLERANCE INDUCTION [J].

ALTERS, SE ;

SHIZURU, JA ;

ACKERMAN, J ;

GROSSMAN, D ;

SEYDEL, KB ;

FATHMAN, CG .

JOURNAL OF EXPERIMENTAL MEDICINE, 1991, 173 (02) :491-494

[2] THE ROLE OF THE T-CELL RECEPTOR IN POSITIVE AND NEGATIVE SELECTION OF DEVELOPING T-CELLS [J].

BLACKMAN, M ;

KAPPLER, J ;

MARRACK, P .

SCIENCE, 1990, 248 (4961) :1335-1341

[3] ALTERED ANTIGEN RECEPTOR SIGNALING IN ANERGIC T-CELLS FROM SELF-TOLERANT T-CELL RECEPTOR BETA-CHAIN TRANSGENIC MICE [J].

BLACKMAN, MA ;

EINKEL, TH ;

KAPPLER, J ;

CAMBIER, J ;

MARRACK, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (15) :6682-6686

[4] GENES ENCODING LIGANDS FOR DELETION OF V-BETA-11 T-CELLS COSEGREGATE WITH MAMMARY-TUMOR VIRUS GENOMES [J].

DYSON, PJ ;

KNIGHT, AM ;

FAIRCHILD, S ;

SIMPSON, E ;

TOMONARI, K .

NATURE, 1991, 349 (6309) :531-532

[5] LINKAGE OF MLS GENES TO ENDOGENOUS MAMMARY-TUMOR VIRUSES OF INBRED MICE [J].

FRANKEL, WN ;

RUDY, C ;

COFFIN, JM ;

HUBER, BT .

NATURE, 1991, 349 (6309) :526-528

[6] SEQUENCES AND FACTORS - A GUIDE TO MHC CLASS-II TRANSCRIPTION [J].

GLIMCHER, LH ;

KARA, CJ .

ANNUAL REVIEW OF IMMUNOLOGY, 1992, 10 :13-49

[7] NOVEL PATHWAYS OF ANTIGEN PRESENTATION FOR THE MAINTENANCE OF MEMORY [J].

GRAY, D ;

KOSCO, M ;

STOCKINGER, B .

INTERNATIONAL IMMUNOLOGY, 1991, 3 (02) :141-148

[8] MOLECULAR EVENTS IN THE INDUCTION OF A NONRESPONSIVE STATE IN INTERLEUKIN 2-PRODUCING HELPER LYMPHOCYTE-T CLONES [J].

JENKINS, MK ;

PARDOLL, DM ;

MIZUGUCHI, J ;

CHUSED, TM ;

SCHWARTZ, RH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (15) :5409-5413

[9] THE T-CELL RECEPTOR V-BETA-6 DOMAIN IMPARTS REACTIVITY TO THE MLS-1A ANTIGEN [J].

KANAGAWA, O ;

PALMER, E ;

BILL, J .

CELLULAR IMMUNOLOGY, 1989, 119 (02) :412-426

[10] T-CELL TOLERANCE BY CLONAL ELIMINATION IN THE THYMUS [J].

KAPPLER, JW ;

ROEHM, N ;

MARRACK, P .

CELL, 1987, 49 (02) :273-280