THE CEPH1 CONSORTIUM LINKAGE MAP OF HUMAN CHROMOSOME-1

被引：147

作者：

DRACOPOLI, NC

OCONNELL, P

ELSNER, TI

LALOUEL, JM

WHITE, RL

BUETOW, KH

NISHIMURA, DY

MURRAY, JC

HELMS, C

MISHRA, SK

DONISKELLER, H

HALL, JM

LEE, MK

KING, MC

ATTWOOD, J

MORTON, NE

ROBSON, EB

MAHTANI, M

WILLARD, HF

ROYLE, NJ

PATEL, I

JEFFREYS, AJ

VERGA, V

JENKINS, T

WEBER, JL

MITCHELL, AL

BALE, AE

机构：

[1] UNIV UTAH,MED CTR,HOWARD HUGHES MED INST,SALT LAKE CITY,UT 84132

[2] UNIV UTAH,MED CTR,DEPT HUMAN GENET,SALT LAKE CITY,UT 84132

[3] FOX CHASE CANC INST,PHILADELPHIA,PA 19111

[4] UNIV IOWA,COLL MED,DEPT PEDIAT,IOWA CITY,IA 52242

[5] WASHINGTON UNIV,DEPT GENET,ST LOUIS,MO 63110

[6] UNIV CALIF BERKELEY,SCH PUBL HLTH,BERKELEY,CA 94720

[7] UNIV LONDON UNIV COLL,GALTON LAB,LONDON NW1 2HE,ENGLAND

[8] UNIV SOUTHAMPTON,DEPT COMMUNITY MED,SOUTHAMPTON SO9 4XY,HANTS,ENGLAND

[9] STANFORD UNIV,MED CTR,SCH MED,DEPT GENET,STANFORD,CA 94305

[10] UNIV LEICESTER,DEPT GENET,LEICESTER LE1 7RH,ENGLAND

[11] S AFRICAN INST MED RES,DEPT HUMAN GENET,MRC HUMAN ECOGENT RES UNIT,JOHANNESBURG 2000,SOUTH AFRICA

[12] UNIV WITWATERSRAND,JOHANNESBURG 2000,SOUTH AFRICA

[13] YALE UNIV,SCH MED,DEPT HUMAN GENET,NEW HAVEN,CT 06510

[14] MARSHFIELD MED RES FDN,MARSHFIELD,WI 54449

来源：

GENOMICS | 1991年 / 9卷 / 04期

关键词：

D O I：

10.1016/0888-7543(91)90362-I

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

This paper describes the Centre d'Etude du Polymorphisme Humain (CEPH) consortium linkage map of human chromosome 1. The map contains 101 loci defined by genotypes generated from CEPH family DNAs with 146 different contributions from 11 laboratories. A total of 58 loci are uniquely placed on the map with likelihood support of at least 1000:1. The map extends from loci in the terminal bands of both chromosome arms (locus D1Z2 in 1p36.3 and D1S68 in 1q44) and is anchored at the centromere by the D1Z5 α-satellite polymorphism. With the exception of a single locus, the remaining loci are arrayed on the fixed map in short intervals and their possible locations are indicated. Multipoint linkage analyses provided estimates that the male, female, and sex-averaged maps extend for 308, 478, and 390 cM, respectively. The sex-averaged map contains only four intervals > 15 cM, and the mean genetic distance between the 58 uniquely placed loci is 6.7 cM. © 1991.

引用

页码：686 / 700

页数：15

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