PROTEASE INHIBITORS ANTAGONIZE THE ACTIVATION OF POLYMORPHONUCLEAR LEUKOCYTE OXYGEN-CONSUMPTION

被引：162

作者：

GOLDSTEIN, BD ^{[1
]}

WITZ, G ^{[1
]}

AMORUSO, M ^{[1
]}

TROLL, W ^{[1
]}

机构：

[1] NYU MED CTR,DEPT MED,NEW YORK,NY 10016

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 88卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0006-291X(79)91487-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We report that the burst of oxygen consumption, as well as the resultant production of O2-• and H2O2, occurring in activated human polymorphonuclear leukocytes is inhibited by various compounds which have in common the ability to antagonize the effects of proteolytic enzymes. This effect of protease inhibitors was observed with a variety of stimuli, both phagocytic and non-phagocytic, used to activate O2-• production in human polymorphonuclear leukocytes. Inhibition was also noted in rat polymorphonuclear leukocytes and alveolar macrophages. The results indicate that proteolysis may be involved in activating the burst of oxygen consumption following stimulation of phagocytic cells. © 1979.

引用

页码：854 / 860

页数：7

共 17 条

[1] INHIBITORY EFFECTS OF SUPEROXIDE DISMUTASES AND VARIOUS OTHER PROTEINS ON NITROBLUE TETRAZOLIUM REDUCTION BY PHAGOCYTIZING GUINEA-PIG POLYMORPHONUCLEAR LEUKOCYTES [J].