UPTAKE OF NITRIC-OXIDE SYNTHASE INHIBITORS BY MACROPHAGE RAW-264.7 CELLS

被引：40

作者：

SCHMIDT, K

KLATT, P

MAYER, B

机构：

[1] Institut Pharmakologie Toxikologie, Karl-Franzens-Universitat Graz, A-8010 Graz

来源：

BIOCHEMICAL JOURNAL | 1994年 / 301卷

关键词：

D O I：

10.1042/bj3010313

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Uptake of the nitric oxide synthase inhibitors N-G-methyl-L-arginine (L-NMA) and N-G-nitro-L-arginine (L-NNA) by macrophages is mediated by two different mechanisms. Activation of the cells with cytokines resulted in an up-regulation of L-NMA uptake but did not affect L-NNA transport. Characterization of the transport sites revealed that uptake of L-NMA is mediated by a cationic amino acid transporter (system y(+)) whereas a neutral amino acid transporter (system L) accounts for the uptake of L-NNA.

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页码：313 / 316

页数：4

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