ANTI-MYCOTIC IMIDAZOLES .4. SYNTHESIS AND ANTIFUNGAL ACTIVITY OF KETOCONAZOLE, A NEW POTENT ORALLY ACTIVE BROAD-SPECTRUM ANTIFUNGAL AGENT

被引：328

作者：

HEERES, J

BACKX, LJJ

MOSTMANS, JH

VANCUTSEM, J

机构：

[1] Janssen Pharmaceutica, Research Laboratoria, B-2340, Beerse

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1979年 / 22卷 / 08期

关键词：

D O I：

10.1021/jm00194a023

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The preparation and antifungal properties of cis-1-acetyl-4-[4-[[2-(2, 4-dichlorophenyl)-2-(1H-imidazol-1-yl-methyl)-1, 3-dioxolan-4-yl]methoxy]phenyl]piperazine (I) are described. Ketoconazole has, at low oral doses, a high in vivo activity against vaginal candidosis in rats and against cutaneous candidosis in guinea pigs. © 1979, American Chemical Society. All rights reserved.

引用

页码：1003 / 1005

页数：3

共 12 条

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[2]

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[3]

BUCHEL KH, 1972, ARZNEI-FORSCHUNG, V22, P1260

[4]

DERANTER C, UNPUBLISHED