SYNTHESIS OF THE MAIN METABOLITE (OL-17) OF CYCLOSPORIN-A

被引：22

作者：

EBERLE, MK

NUNINGER, F

机构：

[1] Preclinical Research, Sandoz Ltd., Basel

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1992年 / 57卷 / 09期

关键词：

D O I：

10.1021/jo00035a027

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Acetyl-cyclosporin A (2) was subjected to the conditions of allylic radical bromination to give 3. Exchange of the bromide by acetoxy led to 4 which was hydrolyzed to the known metabolite OL-17 (5) of cyclosporin A (1).

引用

页码：2689 / 2691

页数：3

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