IMMUNOGENETIC PREDICTION OF PULMONARY FIBROSIS IN SYSTEMIC-SCLEROSIS

被引：113

作者：

BRIGGS, DC

VAUGHAN, RW

WELSH, KI

MYERS, A

DUBOIS, RM

BLACK, CM

机构：

[1] TEMPLE UNIV,HLTH SCI CTR,PHILADELPHIA,PA 19140

[2] ROYAL BROMPTON HOSP,DEPT THORAC MED,LONDON,ENGLAND

[3] ROYAL FREE HOSP,DEPT RHEUMATOL,LONDON,ENGLAND

来源：

LANCET | 1991年 / 338卷 / 8768期

关键词：

D O I：

10.1016/0140-6736(91)91235-M

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

75 systemic sclerosis patients were independently tested for pulmonary fibrosis, autoantibodies, and MHC class II genes. 24 of 42 (57%) patients with pulmonary fibrosis had either HLA DR3/DRw52a or anti-Scl-70 vs 2 of 33 (6%) patients without pulmonary fibrosis. The presence of DR3/DRw52a or anti-Scl-70 gives a relative risk of 16.7 for the development of pulmonary fibrosis in a patient with scleroderma-a risk substantial enough to require careful monitoring of these patients and treatment at an early stage of disease.

引用

页码：661 / 662

页数：2

共 8 条

[1] DNA-RFLP ANALYSIS AND GENOTYPING OF HLA-DR AND DQ ANTIGENS [J].