A MOLECULAR-MODEL OF MHC CLASS-I-RESTRICTED ANTIGEN PROCESSING

被引：468

作者：

MONACO, JJ

机构：

[1] Department of Microbiology and Immunology, Medical College of Virginia, Virginia Commonwealth University, Richmond

来源：

IMMUNOLOGY TODAY | 1992年 / 13卷 / 05期

关键词：

D O I：

10.1016/0167-5699(92)90122-N

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cells of higher vertebrates have evolved mechanisms that allow a sample of their intracellular contents to be available for surveillance by the immune system. This display of intracellular material is in the form of peptides bound to cell surface major histocompatibility complex (MHC) class I molecules. In this review, John Monaco presents a model of the mechanisms by which this takes place, based on the recent identification of a number of new genes in the MHC.

引用

页码：173 / 178

页数：6

共 69 条

[1] ENDOGENOUSLY SYNTHESIZED PEPTIDE WITH AN ENDOPLASMIC-RETICULUM SIGNAL SEQUENCE SENSITIZES ANTIGEN PROCESSING MUTANT-CELLS TO CLASS-I-RESTRICTED CELL-MEDIATED LYSIS [J].

ANDERSON, K ;

CRESSWELL, P ;

GAMMON, M ;

HERMES, J ;

WILLIAMSON, A ;

ZWEERINK, H .

JOURNAL OF EXPERIMENTAL MEDICINE, 1991, 174 (02) :489-492

[2] HAM-2 CORRECTS THE CLASS-I ANTIGEN-PROCESSING DEFECT IN RMA-S CELLS [J].

ATTAYA, M ;

JAMESON, S ;

MARTINEZ, CK ;

HERMEL, E ;

ALDRICH, C ;

FORMAN, J ;

LINDAHL, KF ;

BEVAN, MJ ;

MONACO, JJ .

NATURE, 1992, 355 (6361) :647-649

[3] PEPTIDE BINDING TO EMPTY HLA-B27 MOLECULES OF VIABLE HUMAN-CELLS [J].

BENJAMIN, RJ ;

MADRIGAL, JA ;

PARHAM, P .

NATURE, 1991, 351 (6321) :74-77

[4] STRUCTURE OF THE HUMAN CLASS-I HISTOCOMPATIBILITY ANTIGEN, HLA-A2 [J].

BJORKMAN, PJ ;

SAPER, MA ;

SAMRAOUI, B ;

BENNETT, WS ;

STROMINGER, JL ;

WILEY, DC .

NATURE, 1987, 329 (6139) :506-512

[5] THE FOREIGN ANTIGEN-BINDING SITE AND T-CELL RECOGNITION REGIONS OF CLASS-I HISTOCOMPATIBILITY ANTIGENS [J].

BJORKMAN, PJ ;

SAPER, MA ;

SAMRAOUI, B ;

BENNETT, WS ;

STROMINGER, JL ;

WILEY, DC .

NATURE, 1987, 329 (6139) :512-518

[6] ANTIGEN PRESENTATION PATHWAYS TO CLASS-I AND CLASS-II MHC-RESTRICTED LYMPHOCYTES-T [J].

BRACIALE, TJ ;

MORRISON, LA ;

SWEETSER, MT ;

SAMBROOK, J ;

GETHING, MJ ;

BRACIALE, VL .

IMMUNOLOGICAL REVIEWS, 1987, 98 :95-114

[7] STRUCTURAL AND SEROLOGICAL SIMILARITY OF MHC-LINKED LMP AND PROTEASOME (MULTICATALYTIC PROTEINASE) COMPLEXES [J].

BROWN, MG ;

DRISCOLL, J ;

MONACO, JJ .

NATURE, 1991, 353 (6342) :355-357

[8] INDUCTION OF CYTO-TOXIC LYMPHOCYTES-T BY PRIMARY INVITRO STIMULATION WITH PEPTIDES [J].

CARBONE, FR ;

MOORE, MW ;

SHEIL, JM ;

BEVAN, MJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 1988, 167 (06) :1767-1779

[9] PRESENTATION OF VIRAL-ANTIGEN CONTROLLED BY A GENE IN THE MAJOR HISTOCOMPATIBILITY COMPLEX [J].

CERUNDOLO, V ;

ALEXANDER, J ;

ANDERSON, K ;

LAMB, C ;

CRESSWELL, P ;

MCMICHAEL, A ;

GOTCH, F ;

TOWNSEND, A .

NATURE, 1990, 345 (6274) :449-452

[10] THE BINDING-AFFINITY AND DISSOCIATION RATES OF PEPTIDES FOR CLASS-I MAJOR HISTOCOMPATIBILITY COMPLEX-MOLECULES [J].

CERUNDOLO, V ;

ELLIOTT, T ;

ELVIN, J ;

BASTIN, J ;

RAMMENSEE, HG ;

TOWNSEND, A .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1991, 21 (09) :2069-2075

← 1 2 3 4 5 6 7 →