SUSCEPTIBILITY OR RESISTANCE TO LYSIS BY ALLOREACTIVE NATURAL-KILLER-CELLS IS GOVERNED BY A GENE IN THE HUMAN MAJOR HISTOCOMPATIBILITY COMPLEX BETWEEN BF AND HLA-B

被引：69

作者：

CICCONE, E

COLONNA, M

VIALE, O

PENDE, D

DIDONATO, C

REINHARZ, D

AMOROSO, A

JEANNET, M

GUARDIOLA, J

MORETTA, A

SPIES, T

STROMINGER, J

MORETTA, L

机构：

[1] UNIV GENOA, CTR INTERUNIV RIC CANC, I-16126 GENOA, ITALY

[2] UNIV GENOA, IST ISTOL & EMBRIOL GEN, I-16126 GENOA, ITALY

[3] HOP CANTONAL GENEVA, UNITE IMMUNOL & TRANSPLANTAT, CH-1211 GENEVA 4, SWITZERLAND

[4] UNIV TURIN, IST GENET MED, I-10124 TURIN, ITALY

[5] HARVARD UNIV, SCH MED, DANA FARBER CANC INST, DIV TUMOR VIROL, BOSTON, MA 02115 USA

[6] IST INT GENET & BIOFIS, NAPLES, ITALY

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1990年 / 87卷 / 24期

关键词：

D O I：

10.1073/pnas.87.24.9794

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The specificity recognized on normal allogeneic cells by a given alloreactive (1-anti-A) natural killer clone is controlled by a gene locus termed EC1. Because the EC1 locus was previously shown to be located on chromosome 6, families characterized by a recombinant major histocompatibility complex haplotype were analyzed to map this locus more precisely. The breakpoint of recombination was studied by standard HLA typing, complement typing, and restriction fragment length polymorphism analysis of a series of genes located between the complement cluster genes and HLA-B within the major histocompatibility complex region. Three of 10 families analyzed were informative. From the data obtained, the EC1 locus maps between BF and HLA-B and presumably is one of the normal genes recently described in this region.

引用

页码：9794 / 9797

页数：4

共 16 条

[1] GENETIC POLYMORPHISM IN HUMAN GLYCINE-RICH BETA-GLYCOPROTEIN [J].