CHARACTERIZATION OF RECF SUPPRESSORS IN BACILLUS-SUBTILIS

被引：22

作者：

ALONSO, JC

LUDER, G

机构：

[1] Max-Planck Institut für Molekulare Genetik, D-1000 Berlin 33

来源：

BIOCHIMIE | 1991年 / 73卷 / 2-3期

关键词：

RECF GENE; SOS INDUCTION; DNA REPAIR; RECA; SSB;

D O I：

10.1016/0300-9084(91)90213-K

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A recF mutation renders Bacillus subtilis cells very sensitive to DNA-damaging agents. Such a recF defect is partially suppressed either by the presence of the recA73 mutation or by the presence of a plasmid-borne, heterologous, single-stranded DNA-binding (ssb) protein gene. Plasmids carrying ssb genes also suppressed the recR and recL defects. Our results suggest that suppression occurs by increasing recombinational repair. The effect of the suppressors may be at the level of induction of the SOS response.

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页码：277 / 280

页数：4

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