REGIONAL AND SPECIES-DIFFERENCES IN ENDOGENOUS PROSTAGLANDIN BIOSYNTHESIS BY BRAIN HOMOGENATES

被引：109

作者：

ABDELHALIM, MS ^{[1
]}

ANGGARD, E ^{[1
]}

机构：

[1] KAROLINSKA INST,DEPT ALCOHOL & DRUG ADDICT,S-10401 STOCKHOLM 60,SWEDEN

来源：

PROSTAGLANDINS | 1979年 / 17卷 / 03期

关键词：

D O I：

10.1016/S0090-6980(79)80009-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Endogenously formed prostaglandins (PGs) D2, E2 and F2α were determined in homogenates of brain regions from rat, guinea-pig, rabbit and cat, using gas-chromatography-mass spectrometry. The main PGs formed in the brain regions of the rat were PGD2, in the guinea-pig PGD2 and PGF2α, in the rabbit PGF2α and in the cat PGE2. Brain regions from the same animal species showed the same pattern of PG formation. They varied, however, in the amount of total PGs formed, the limbic system and the cerebral cortex being highest and cerebellum lowest. © 1979.

引用

页码：411 / 418

页数：8

共 6 条

[1] IDENTIFICATION OF PROSTAGLANDIN D2 AS A MAJOR PROSTAGLANDIN IN HOMOGENATES OF RAT-BRAIN [J].

ABDELHALIM, MS ;

HAMBERG, M ;

SJOQUIST, B ;

ANGGARD, E .

PROSTAGLANDINS, 1977, 14 (04) :633-643

[2]

BENNETT A, 1977, BRIT J PHARMACOL, V59, pP448

[3]

NICOSIA S, 1975, Prostaglandins, V9, P397, DOI 10.1016/0090-6980(75)90145-8

[4] IDENTIFICATION OF SMOOTH MUSCLE-STIMULATING FACTOR IN BOVINE BRAIN PROSTAGLANDINS + RELATED FACTORS 25 [J].

SAMUELSSON, B .

BIOCHIMICA ET BIOPHYSICA ACTA, 1964, 84 (02) :218-&

[5] ENDOGENOUS BIOSYNTHESIS OF PROSTAGLANDINS BY BRAIN-TISSUE INVITRO [J].

WOLFE, LS ;

ROSTWOROWSKI, K ;

PAPPIUS, HM .

CANADIAN JOURNAL OF BIOCHEMISTRY, 1976, 54 (07) :629-640

[6] ENDOGENOUS FORMATION OF PROSTAGLANDIN ENDOPEROXIDE METABOLITE, THROMBOXANE B2, BY BRAIN-TISSUE [J].

WOLFE, LS ;

ROSTWOROWSKI, K ;

MARION, J .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1976, 70 (03) :907-913

← 1 →