THE EFFECTS OF THIMEROSAL, A SULFHYDRYL REAGENT, ON PHASIC MYOMETRIAL CONTRACTIONS

被引：6

作者：

PHILLIPPE, M

机构：

[1] Department of Obstetrics and Gynecology, University of Chicago

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 211卷 / 01期

关键词：

D O I：

10.1006/bbrc.1995.1769

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Thimerosal inhibits calcium uptake and IP3-induced calcium release from IP3-sensitive endoplasmic reticulum; this study sought to evaluate the effects of thimerosal on agonist-stimulated phasic myometrial contractions. Thimerosal was found to significantly inhibit phasic contractions stimulated by oxytocin, aluminum fluoride, potassium chloride, ionomycin, and Bay K 8644. These observations provide support for the hypothesis that calcium uptake and IP3-induced calcium release are important events during agonist-stimulated phasic myometrial contractions. (C) 1995 Academic Press. Inc.

引用

页码：1 / 6

页数：6

共 24 条

[1] REQUIREMENT FOR CALCIUM-IONS IN ACETYLCHOLINE-STIMULATED PHOSPHODIESTERATIC CLEAVAGE OF PHOSPHATIDYL-MYO-INOSITOL 4,5-BISPHOSPHATE IN RABBIT IRIS SMOOTH-MUSCLE [J].