G-PROTEIN-COUPLED RECEPTORS - TURNED ON TO ILL EFFECT

被引：93

作者：

LEFKOWITZ, RJ

机构：

来源：

NATURE | 1993年 / 365卷 / 6447期

关键词：

D O I：

10.1038/365603a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

引用

页码：603 / 604

页数：2

共 15 条

[1] G-PROTEIN-COUPLED RECEPTOR GENES AS PROTOONCOGENES - CONSTITUTIVELY ACTIVATING MUTATION OF THE ALPHA-1B-ADRENERGIC RECEPTOR ENHANCES MITOGENESIS AND TUMORIGENICITY [J].

ALLEN, LF ;

LEFKOWITZ, RJ ;

CARON, MG ;

COTECCHIA, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (24) :11354-11358

[2] SPECIFIC ACTIVATION OF GS BY SYNTHETIC PEPTIDES CORRESPONDING TO AN INTRACELLULAR LOOP OF THE BETA-ADRENERGIC-RECEPTOR [J].

CHEUNG, AH ;

HUANG, RRC ;

GRAZIANO, MP ;

STRADER, CD .

FEBS LETTERS, 1991, 279 (02) :277-280

[3] REGIONS OF THE ALPHA-1-ADRENERGIC RECEPTOR INVOLVED IN COUPLING TO PHOSPHATIDYLINOSITOL HYDROLYSIS AND ENHANCED SENSITIVITY OF BIOLOGICAL FUNCTION [J].

COTECCHIA, S ;

EXUM, S ;

CARON, MG ;

LEFKOWITZ, RJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (08) :2896-2900

[4] ECTOPIC EXPRESSION OF THE SEROTONIN 1C RECEPTOR AND THE TRIGGERING OF MALIGNANT TRANSFORMATION [J].

JULIUS, D ;

LIVELLI, TJ ;

JESSELL, TM ;

AXEL, R .

SCIENCE, 1989, 244 (4908) :1057-1062

[5]

KJELSBERG MA, 1992, J BIOL CHEM, V267, P1430

[6] CONSTITUTIVE ACTIVITY OF RECEPTORS COUPLED TO GUANINE-NUCLEOTIDE REGULATORY PROTEINS [J].

LEFKOWITZ, RJ ;

COTECCHIA, S ;

SAMAMA, P ;

COSTA, T .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1993, 14 (08) :303-307

[7]

OKAMOTO T, 1991, CELL, V67, P1

[8] SOMATIC MUTATIONS IN THE THYROTROPIN RECEPTOR GENE CAUSE HYPERFUNCTIONING THYROID ADENOMAS [J].

PARMA, J ;

DUPREZ, L ;

VANSANDE, J ;

COCHAUX, P ;

GERVY, C ;

MOCKEL, J ;

DUMONT, J ;

VASSART, G .

NATURE, 1993, 365 (6447) :649-651

[9]

REN Q, 1993, J BIOL CHEM, V268, P16483

[10] PIGMENTATION PHENOTYPES OF VARIANT EXTENSION LOCUS ALLELES RESULT FROM POINT MUTATIONS THAT ALTER MSH RECEPTOR FUNCTION [J].

ROBBINS, LS ;

NADEAU, JH ;

JOHNSON, KR ;

KELLY, MA ;

ROSELLIREHFUSS, L ;

BAACK, E ;

MOUNTJOY, KG ;

CONE, RD .

CELL, 1993, 72 (06) :827-834

← 1 2 →