SIGNAL PEPTIDASES IN PROKARYOTES AND EUKARYOTES - A NEW PROTEASE FAMILY

被引：188

作者：

DALBEY, RE ^{[1
]}

VONHEIJNE, G ^{[1
]}

机构：

[1] NOVUM,KAROLINSKA INST CTR STRUCT BIOCHEM,DEPT MOLEC BIOL,S-14157 HUDDINGE,SWEDEN

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1992年 / 17卷 / 11期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/0968-0004(92)90492-R

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Signal peptidases remove targeting peptides from pre-proteins and play central roles in the secretory pathway, as well as in the delivery of proteins to the mitochondrial intermembrane space and to the lumen of thylakoids. The catalytic mechanism of pre-protein cleavage has long been an enigma, but recent data from site-directed mutagenesis and sequence alignment studies suggest that signal peptidases may constitute a new type of serine protease, mechanistically related to the beta-lactamases.

引用

页码：474 / 478

页数：5

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