ROLE OF ARACHIDONIC-ACID DERIVATIVES IN NEUTROPHIL AGGREGATION - HYPOTHESIS

被引：35

作者：

OFLAHERTY, JT

SHOWELL, HJ

BECKER, EL

WARD, PA

机构：

[1] Department of Pathology University, Connecticut Health Center Farmington

来源：

PROSTAGLANDINS | 1979年 / 17卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0090-6980(79)90062-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chemotactic substances stimulate neutrophils in suspension to aggregate. Arachidonic acid (but not several structurally related fatty acids) induces a similar neutrophil response. We now report that two blockers of arachidonic acid metabolism, indomethacin and 5,8,11,14-eicosatetraynoic acid, inhibit this arachidonic acid-mediated response. Moreover, both blockers also inhibit aggregation stimulated by a synthetic chemotactic tripeptide, formyl-methionyl-leucyl-phenylalanine, and their potency in doing so parallels their potency in inhibiting the response to arachidonic acid. These results suggest that metabolites of arachidonic acid may stimulate certain neutrophil functions and be involved in cellular responses to at least some chemotactic substances. © 1979.

引用

页码：915 / 927

页数：13

共 35 条

[1]

BELLS TK, 1976, BIOCH BIOPHYS ACTA, V424, P303

[2] DISTRIBUTION AND METABOLISM OF ARACHIDONIC-ACID IN RABBIT PLATELETS DURING AGGREGATION AND ITS MODIFICATION BY DRUGS [J].