COMPARISON OF THE ACTIONS OF DIAZEPAM AND LORAZEPAM

被引：75

作者：

DUNDEE, JW ^{[1
]}

MCGOWAN, WAW ^{[1
]}

LILBURN, JK ^{[1
]}

MCKAY, AC ^{[1
]}

HEGARTY, JE ^{[1
]}

机构：

[1] QUEENS UNIV BELFAST, DEPT ANAESTHET, BELFAST BT7 1NN, ANTRIM, NORTH IRELAND

来源：

BRITISH JOURNAL OF ANAESTHESIA | 1979年 / 51卷 / 05期

关键词：

D O I：

10.1093/bja/51.5.439

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Diazepam and lorazepam differ in potency and in the time-course of their action in patients. As a sedative, diazepam 10 mg is equivalent to lorazepam 2-2.5 mg. Diazepam, but not lorazepam, is better absorbed after oral than after i.m. administrations. The clinical effect and amnesia begin more rapidly with diazepam but last longer following lorazepam. Lorazepam is more effective than diazepam in blocking the emergence sequelae from ketamine. Lorazepam i.v. is followed by a lesser frequency of venous thrombosis.

引用

页码：439 / 446

页数：8

共 20 条

[1] INFLUENCE OF ROUTE OF ADMINISTRATION ON CLINICAL ACTION OF DIAZEPAM [J].

ASSAF, RAE ;

DUNDEE, JW ;

GAMBLE, JAS .

ANAESTHESIA, 1975, 30 (02) :152-158

[2] TAMING OF KETAMINE [J].

COPPEL, DL ;

BOVILL, JG ;

DUNDEE, JW .

ANAESTHESIA, 1973, 28 (03) :293-296

[3] STUDIES OF DRUGS GIVEN BEFORE ANAESTHESIA .1. A METHOD OF PRE-OPERATIVE ASSESSMENT [J].

DUNDEE, JW ;

MOORE, J ;

NICHOLL, RM .

BRITISH JOURNAL OF ANAESTHESIA, 1962, 34 (07) :458-&

[4] PLASMA LORAZEPAM LEVELS - STUDY FOLLOWING SINGLE DOSE ADMINISTRATION OF 2 AND 4 MG BY DIFFERENT ROUTES [J].

DUNDEE, JW ;

LILBURN, JK ;

TONER, W ;

HOWARD, PJ .

ANAESTHESIA, 1978, 33 (01) :15-19

[5] KETAMINE-LORAZEPAM - ATTENUATION OF PSYCHIC SEQUELAE OF KETAMINE BY LORAZEPAM [J].

DUNDEE, JW ;

LILBURN, JK .

ANAESTHESIA, 1978, 33 (04) :312-314

[6] STUDIES OF DRUGS GIVEN BEFORE ANESTHESIA .26. LORAZEPAM [J].

DUNDEE, JW ;

LILBURN, JK ;

NAIR, SG ;

GEORGE, KA .

BRITISH JOURNAL OF ANAESTHESIA, 1977, 49 (10) :1047-1056

[7]

DUNDEE JW, 1976, INTRAVENOUS ANAESTHE

[8]

ERBGUTH PH, 1972, ANESTH ANAL CURR RES, V51, P693

[9] COMPARISON OF LORAZEPAM AND DIAZEPAM AS PREMEDICANTS [J].

GALLOON, S ;

GALE, GD ;

LANCEE, WJ .

BRITISH JOURNAL OF ANAESTHESIA, 1977, 49 (12) :1265-1269

[10] SOME FACTORS INFLUENCING ABSORPTION OF DIAZEPAM [J].

GAMBLE, JAS .

PROCEEDINGS OF THE ROYAL SOCIETY OF MEDICINE-LONDON, 1975, 68 (12) :772-772

← 1 2 →