METABOLIC CONTROL ANALYSIS - THE EFFECTS OF HIGH ENZYME CONCENTRATIONS

被引：35

作者：

FELL, DA ^{[1
]}

SAURO, HM ^{[1
]}

机构：

[1] UNIV EDINBURGH, DEPT GENET, EDINBURGH EH8 9YL, MIDLOTHIAN, SCOTLAND

来源：

EUROPEAN JOURNAL OF BIOCHEMISTRY | 1990年 / 192卷 / 01期

基金：

英国惠康基金;

关键词：

D O I：

10.1111/j.1432-1033.1990.tb19212.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Differing views have been given in the literature as to whether the presence in a pathway of an enzyme at a concentration comparable to that of its substrate affects the values of control coefficients and the theorems of metabolic control analysis. Here we argue in favour of one of those views: that there is no effect unless the enzyme sequesters a substrate that contains a conserved moiety. In this particular case, we derive both a general criterion for estimating whether such an effect will be of a significant magnitude, and equations for determining the changes in the flux control coefficients. The nature of the phenomenom and the application of the equations are illustrated with a numerical simulation. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：183 / 187

页数：5

共 16 条

[1] CONTROL ANALYSIS OF METABOLIC SYSTEMS [J].

BURNS, JA ;

CORNISHBOWDEN, A ;

GROEN, AK ;

HEINRICH, R ;

KACSER, H ;

PORTEOUS, JW ;

RAPOPORT, SM ;

RAPOPORT, TA ;

STUCKI, JW ;

TAGER, JM ;

WANDERS, RJA ;

WESTERHOFF, HV .

TRENDS IN BIOCHEMICAL SCIENCES, 1985, 10 (01) :16-16

[2]

BURNS JA, 1971, THESIS U EDINBURGH

[3]

EASTERBY J, 1990, IN PRESS CONTROL MET

[4] METABOLIC CONTROL AND ITS ANALYSIS - ADDITIONAL RELATIONSHIPS BETWEEN ELASTICITIES AND CONTROL COEFFICIENTS [J].

FELL, DA ;

SAURO, HM .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1985, 148 (03) :555-561

[5] CONTROL ANALYSIS OF METABOLIC NETWORKS .1. HOMOGENEOUS FUNCTIONS AND THE SUMMATION THEOREMS FOR CONTROL COEFFICIENTS [J].

GIERSCH, C .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1988, 174 (03) :509-513

[6] LINEAR STEADY-STATE TREATMENT OF ENZYMATIC CHAINS - GENERAL PROPERTIES, CONTROL AND EFFECTOR STRENGTH [J].

HEINRICH, R ;

RAPOPORT, TA .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1974, 42 (01) :89-95

[7]

HEINRICH R, 1977, PROG BIOPHYS MOL BIO, V32, P1

[8] METABOLIC CONTROL ANALYSIS OF MOIETY-CONSERVED CYCLES [J].

HOFMEYR, JHS ;

KACSER, H ;

VANDERMERWE, KJ .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1986, 155 (03) :631-641

[9] ENZYME-ENZYME INTERACTIONS AND CONTROL ANALYSIS .1. THE CASE OF NONADDITIVITY - MONOMER-OLIGOMER ASSOCIATIONS [J].

KACSER, H ;

SAURO, HM ;

ACERENZA, L .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1990, 187 (03) :481-491

[10]

Kacser H, 1973, Symp Soc Exp Biol, V27, P65

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