SIMILARITIES BETWEEN A UV-SENSITIVE MUTANT OF YEAST AND BACTERIAL MUTANTS LACKING EXCISION-REPAIR ABILITY

A UV-sensitive and a wild-type strain of Saccharomyces cerevisiae have been compared with respect to their responses to photoreactivation, retention of the capacity to photoreactivate when stored at 32°C in buffer, and sensitivity to diepoxybutane and nitrosoguanidine. In all these tests the behaviour of the sensitive mutant paralleled bacterial strains lacking excision repair ability. We may tentatively attribute the UV sensitivity in this mutant to a loss of some element of a repair system analogous to excision repair in bacteria. © 1969 Springer-Verlag.