CLONAL SPREAD OF SEROGROUP-A MENINGOCOCCI - A PARADIGM FOR THE ANALYSIS OF MICROEVOLUTION IN BACTERIA

被引：58

作者：

ACHTMAN, M

机构：

[1] Max-Planck Institut für molekulare Genetik, Berlin, D-14195

来源：

MOLECULAR MICROBIOLOGY | 1994年 / 11卷 / 01期

关键词：

D O I：

10.1111/j.1365-2958.1994.tb00285.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Extensive epidemiological analyses of epidemics of meningococcal meningitis have resulted in large, well-defined strain collections which represent the local diversity and global spread of serogroup A bacteria. Several genes for cell surface proteins are conserved during spread, with a few exceptions: analysis of these exceptions has revealed some of the phenomena which can lead to microevolution. Microevolution is so rapid with serogroup A meningococci that several independent recombination events have been documented within the last few decades. In a few cases, the recombinant bacteria have become established by clonal replacement plus epidemic spread. Comparison with other bacteria indicates that serogroup A meningococci provide a number of advantages for analysis of microevolution.

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页码：15 / 22

页数：8

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