AGE-DEPENDENT INCREASE IN [H3] VERAPAMIL BINDING TO RAT CORTICAL MEMBRANES

被引：29

作者：

BATTAINI, F ^{[1
]}

GOVONI, S ^{[1
]}

RIUS, RA ^{[1
]}

TRABUCCHI, M ^{[1
]}

机构：

[1] UNIV ROME 2, CHAIR TOXICOL, ROME, ITALY

来源：

NEUROSCIENCE LETTERS | 1985年 / 61卷 / 1-2期

关键词：

D O I：

10.1016/0304-3940(85)90402-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

[3H]Nitrendipine bound to cerebral cortex membranes is displaced more efficiently by verapamil in old rats (24 months old) compared to young ones (3 months old). In addition, [3H]verapamil binding was studied in detail in 3-, 12- and 24-month-old rats. Aging increases the Bmax of [3H]verapamil, leaving the affinity unchanged. These observations further indicate that aging may affect calcium channels leading to a derangement of calcium movements which in turn may alter neuronal activity.

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页码：67 / 71

页数：5

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