COMPLEMENT ACTIVATION DURING SUBSEQUENT STAGES OF CANINE ENDOTOXIN-SHOCK

被引：10

作者：

AASEN, AO

MELLBYE, OJ

OHLSSON, K

机构：

[1] MALMO GEN HOSP, DEPT SURG, S-21401 MALMO, SWEDEN

[2] RIKSHOSP OSLO, NATL HOSP NORWAY, INST IMMUNOL & RHEUMATOL, OSLO, NORWAY

来源：

SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 1978年 / 8卷 / 06期

关键词：

D O I：

10.1111/j.1365-3083.1978.tb00550.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Changes in total hemolytic complement (C) and levels of C3, C4 and C6 were studied during subsequent stages of lethal [Escherichia coli] endotoxin shock in dogs. Substantial decreases of all parameters were observed. C4 and C6 decreases showed a very similar pattern, indicating activation of C by the classical pathway in addition to the activation of the alternative pathway known to occur in this pathological condition. The role of the C system in the pathophysiology of endotoxin shock are emphasized. C activation has prognostic value during endotoxemia.

引用

页码：509 / 513

页数：5

共 26 条

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