NMDA AND QUISQUALATE REDUCE A CA-DEPENDENT K+ CURRENT BY A PROTEIN KINASE-MEDIATED MECHANISM

被引：75

作者：

BASKYS, A

BERNSTEIN, NK

BAROLET, AW

CARLEN, PL

机构：

[1] ADDICT RES FDN,TORONTO M5S 2S1,ONTARIO,CANADA

[2] UNIV TORONTO,DEPT PHYSIOL,TORONTO M5S 1A1,ONTARIO,CANADA

[3] UNIV TORONTO,DIV LIFE SCI,SCARBOROUGH,ONTARIO,CANADA

来源：

NEUROSCIENCE LETTERS | 1990年 / 112卷 / 01期

关键词：

Calcium-dependent potassium current; Dentate granule neuron; N-Methyl-d-aspartate; Protein kinase inhibitor; Quisqualate; α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid;

D O I：

10.1016/0304-3940(90)90325-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Stimulation of N-methyl-d-aspartate (NMDA) or quisqualate (Quis) receptors by submicromolar concentrations of NMDA or Quis but not α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) reduced post-spike train afterhyperpolarizations (AHPs) and blocked the underlying Iaph in dentate granule (DG) neurones in vitro. The NMDA but not Quis action was blocked by the NMDA receptor blocker 2-d,l-aminophosphonovaleric acid (APV). Actions of both NMDA and Quis were abolished by isoquino-linesulphonyl-2-methyl-piperazine dihydrochloride (H-7), an inhibitor of several protein kinases. These data suggest that there is a link between excitatory amino acid receptor activation, the protein kinase system, and neuronal excitability. © 1990.

引用

页码：76 / 81

页数：6

共 25 条

[1] PROTEIN KINASE-C REGULATES IONIC CONDUCTANCE IN HIPPOCAMPAL PYRAMIDAL NEURONS - ELECTROPHYSIOLOGICAL EFFECTS OF PHORBOL ESTERS [J].