THE EFFECT OF CANNABIDIOL ON MOUSE HEPATIC-MICROSOMAL CYTOCHROME P450-DEPENDENT ANANDAMIDE METABOLISM

被引：51

作者：

BORNHEIM, LM ^{[1
]}

KIM, KY ^{[1
]}

CHEN, BL ^{[1
]}

CORREIA, MA ^{[1
]}

机构：

[1] UNIV CALIF SAN FRANCISCO,CTR LIVER,CORE FACIL,SAN FRANCISCO,CA 94143

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 197卷 / 02期

关键词：

D O I：

10.1006/bbrc.1993.2541

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Anandamide (arachidonylethanolamide) has been identified as a brain constituent that selectively binds to the cannabinoid receptor and possesses cannabimimetic activity. Cytochromes P450 catalyze the oxidation of arachidonic acid to several metabolites possessing very potent pharmacological activity. We examined whether P450 would also metabolize anandamide, and whether cannabidiol (a cannabinoid which inactivates several P450s) would affect this metabolism. Mouse hepatic P450s were found to metabolize anandamide to at least 10 different metabolites, four of which were characterized by mass spectrometry. Cannabidiol selectively inhibited the formation of two of these four anandamide metabolites. The significance of anandamide metabolism remains to be explored. © 1993 Academic Press, Inc.

引用

页码：740 / 746

页数：7

共 21 条

[1] EFFECT OF CANNABIDIOL ON CYTOCHROME-P-450 AND HEXOBARBITAL SLEEP TIME [J].

BORNHEIM, LM ;

BORYS, HK ;

KARLER, R .

BIOCHEMICAL PHARMACOLOGY, 1981, 30 (05) :503-507

[2] EFFECT OF CANNABIDIOL ON CYTOCHROME-P-450 ISOZYMES [J].

BORNHEIM, LM ;

CORREIA, MA .

BIOCHEMICAL PHARMACOLOGY, 1989, 38 (17) :2789-2794

[3]

BORNHEIM LM, 1989, BIOCH PHYSL SUBSTANC, V1, P21

[4] THE OXIDATIVE-METABOLISM OF ARACHIDONIC-ACID BY PURIFIED CYTOCHROMES P-450 [J].

CAPDEVILA, J ;

PARKHILL, L ;

CHACOS, N ;

OKITA, R ;

MASTERS, BSS ;

ESTABROOK, RW .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1981, 101 (04) :1357-1363

[5] RATIONALLY DESIGNED, POTENT COMPETITIVE INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS [J].

COREY, EJ ;

CASHMAN, JR ;

KANTNER, SS ;

WRIGHT, SW .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1984, 106 (05) :1503-1504

[6]

CORREIA MA, 1993, MED IMPLICATIONS CYT, P74

[7]

DALTON WS, 1976, CLIN PHARMACOL THER, V19, P300

[8]

DEVANE WA, 1988, MOL PHARMACOL, V34, P605

[9] ISOLATION AND STRUCTURE OF A BRAIN CONSTITUENT THAT BINDS TO THE CANNABINOID RECEPTOR [J].

DEVANE, WA ;

HANUS, L ;

BREUER, A ;

PERTWEE, RG ;

STEVENSON, LA ;

GRIFFIN, G ;

GIBSON, D ;

MANDELBAUM, A ;

ETINGER, A ;

MECHOULAM, R .

SCIENCE, 1992, 258 (5090) :1946-1949

[10]

ESCALANTE B, 1989, J PHARMACOL EXP THER, V248, P229

← 1 2 3 →