METABOLISM OF PROGESTERONE-4-14C IN VITRO IN HUMAN SKIN AND VAGINAL MUCOSA

被引：35

作者：

FROST, P

GOMEZ, EC

WEINSTEIN, GD

LAMAS, J

HSIA, SL

机构：

[1] Departments of Dermatology, Biochemistry, University of Miami, School of Medicine, Miami, Florida

来源：

BIOCHEMISTRY | 1969年 / 8卷 / 03期

关键词：

D O I：

10.1021/bi00831a027

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Progesterone-4-14C was found to be actively metabolized by minces of human skin and vaginal mucosa. by paper and thin-layer chromatography, isotopic dilution, and the preparation of chromic acid oxidation products, acetates and methoximes, the following metabolites were identified: 5α-pregnane- 3,20-dione, 5α-pregnan-3α-ol-20-one, 5α-pregnan-3β-ol-20-one, 5α-pregnane-3β,20α-diol, Δ4-pregnen-20α-ol-3-one, and 5α-pregnan-3β-20α-diol. The major metabolic pathways of progesterone in human skin and vaginal mucosa involve reduction of the 20-one to 20α-ol, reduction of the 3-one to 3α-ol and 3β-ol, and the saturation of the 4-5 double bond to form 5α-preg-nanes. No 5β metabolites could be detected. © 1969, American Chemical Society. All rights reserved.

引用

页码：948 / +

页数：1

共 23 条

[1] PROGESTERONE METABOLISM - INVESTIGATION OF THE PRODUCTS OF METABOLISM WITH HUMAN LIVER INVITRO [J].