NUCLEAR TRANSCRIPTS OF MOUSE HEAVY-CHAIN IMMUNOGLOBULIN GENES CONTAIN ONLY THE EXPRESSED CLASS OF C-REGION SEQUENCES

被引：43

作者：

MARCU, KB ^{[1
]}

SCHIBLER, U ^{[1
]}

PERRY, RP ^{[1
]}

机构：

[1] INST CANC RES,FOX CHASE CTR,PHILADELPHIA,PA 19111

来源：

SCIENCE | 1979年 / 204卷 / 4397期

关键词：

D O I：

10.1126/science.109919

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In plasmacytoma cells producing IgG, IgA, or IgM immunoglobulin heavy chains, the large precursors of the heavy chain messenger RNA's contain nucleotide sequences that specify only the expressed class of constant region. This indicates that the switch from one class of heavy chain to another during B cell ontogeny does not occur by altered processing of a complex gene transcript. Copyright © 1979 AAAS.

引用

页码：1087 / 1088

页数：2

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