A MUTANT HUMAN PROINSULIN IS SECRETED FROM ISLETS OF LANGERHANS IN INCREASED AMOUNTS VIA AN UNREGULATED PATHWAY

被引:124
作者
CARROLL, RJ
HAMMER, RE
CHAN, SJ
SWIFT, HH
RUBENSTEIN, AH
STEINER, DF
机构
[1] UNIV CHICAGO,DEPT MED,CHICAGO,IL 60637
[2] UNIV CHICAGO,HOWARD HUGHES MED INST,CHICAGO,IL 60637
[3] UNIV TEXAS,HLTH SCI CTR,SW MED SCH,HOWARD HUGHES MED INST,DALLAS,TX 75235
[4] UNIV CHICAGO,DEPT MOLEC GENET & CELL BIOL,CHICAGO,IL 60637
关键词
D O I
10.1073/pnas.85.23.8943
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
引用
收藏
页码:8943 / 8947
页数:5
相关论文
共 28 条
[1]  
[Anonymous], 1972, ADV PROTEIN CHEM
[2]   MONOMERIC INSULINS OBTAINED BY PROTEIN ENGINEERING AND THEIR MEDICAL IMPLICATIONS [J].
BRANGE, J ;
RIBEL, U ;
HANSEN, JF ;
DODSON, G ;
HANSEN, MT ;
HAVELUND, S ;
MELBERG, SG ;
NORRIS, F ;
NORRIS, K ;
SNEL, L ;
SORENSEN, AR ;
VOIGT, HO .
NATURE, 1988, 333 (6174) :679-682
[3]   FACTORS AFFECTING THE EFFICIENCY OF INTRODUCING FOREIGN DNA INTO MICE BY MICROINJECTING EGGS [J].
BRINSTER, RL ;
CHEN, HY ;
TRUMBAUER, ME ;
YAGLE, MK ;
PALMITER, RD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (13) :4438-4442
[4]   PANCREATIC EXPRESSION OF HUMAN INSULIN GENE IN TRANSGENIC MICE [J].
BUCCHINI, D ;
RIPOCHE, MA ;
STINNAKRE, MG ;
DESBOIS, P ;
LORES, P ;
MONTHIOUX, E ;
ABSIL, J ;
LEPESANT, JA ;
PICTET, R ;
JAMI, J .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (08) :2511-2515
[5]  
BURGESS TL, 1987, ANN REV CELL BIOL, V3, P242
[6]   A MUTATION IN THE B-CHAIN CODING REGION IS ASSOCIATED WITH IMPAIRED PROINSULIN CONVERSION IN A FAMILY WITH HYPERPROINSULINEMIA [J].
CHAN, SJ ;
SEINO, S ;
GRUPPUSO, PA ;
SCHWARTZ, R ;
STEINER, DF .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (08) :2194-2197
[7]   RECOVERY OF DNA SEGMENTS FROM AGAROSE GELS [J].
CHEN, CW ;
THOMAS, CA .
ANALYTICAL BIOCHEMISTRY, 1980, 101 (02) :339-341
[8]   PROINSULIN RADIOIMMUNOASSAY IN THE EVALUATION OF INSULINOMAS AND FAMILIAL HYPERPROINSULINEMIA [J].
COHEN, RM ;
GIVEN, BD ;
LICINIOPAIXAO, J ;
PROVOW, SA ;
RUE, PA ;
FRANK, BH ;
ROOT, MA ;
POLONSKY, KS ;
TAGER, HS ;
RUBENSTEIN, AH .
METABOLISM-CLINICAL AND EXPERIMENTAL, 1986, 35 (12) :1137-1146
[9]   RECEPTOR-MEDIATED ENDOCYTOSIS - CONCEPTS EMERGING FROM THE LDL RECEPTOR SYSTEM [J].
GOLDSTEIN, JL ;
BROWN, MS ;
ANDERSON, RGW ;
RUSSELL, DW ;
SCHNEIDER, WJ .
ANNUAL REVIEW OF CELL BIOLOGY, 1985, 1 :1-39
[10]   FAMILIAL HYPERPROINSULINEMIA DUE TO A PROPOSED DEFECT IN CONVERSION OF PROINSULIN TO INSULIN [J].
GRUPPUSO, PA ;
GORDEN, P ;
KAHN, CR ;
CORNBLATH, M ;
ZELLER, WP ;
SCHWARTZ, R .
NEW ENGLAND JOURNAL OF MEDICINE, 1984, 311 (10) :629-634