CR-15-ETHYLENEDIAMINETETRAACETIC ACID ABSORPTION TEST - EFFECTS OF NAPROXEN, A NONSTEROIDAL, ANTIINFLAMMATORY DRUG

被引：29

作者：

AABAKKEN, L ^{[1
]}

OSNES, M ^{[1
]}

机构：

[1] ULLEVAL HOSP, DEPT MED, GASTROENTEROL SECT, N-0407 OSLO 4, NORWAY

来源：

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY | 1990年 / 25卷 / 09期

关键词：

Clinical trials; Gastrointestinal toxicity; Intestinal permeability; Small bowel;

D O I：

10.3109/00365529008997613

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Eighty volunteers were studied to determine the effects of 750 or 1000 mg naproxen daily for a week on intestinal permeability, by means of the 51Cr-ethylenediamine-tetraacetic acid (EDTA) absorption test. With 750 mg naproxen (n == 42) the median urinary excretion increased from 2.44% to 3.51% (p < 0.01), and with 1000 mg (n == 38) from 2.26% to 3.39% (p < 0.01). When the individual pretreatment absorption was included in the analysis, a statistically significant difference was found between the two doses (19% and 68% median increase as a percentage of base line, respectively (p == 0.04)). Similar results were found in 27 subjects who were given both doses of naproxen. Intraduodenal instillation of the test dose in 18 subjects showed that gastric absorption was negligible, and no correlation was found with upper endoscopy findings, changes in orocoecal transit time, or reported symptoms. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：917 / 924

页数：8

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