ENDOTHELIN INDUCES THROMBOXANE RELEASE AND CONTRACTION OF ISOLATED GUINEA-PIG AIRWAYS

被引：46

作者：

FILEP, JG

BATTISTINI, B

SIROIS, P

机构：

[1] Department of Pharmacology, Faculty of Medicine, University of Sherbrooke, Sherbrooke

来源：

LIFE SCIENCES | 1990年 / 47卷 / 20期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0024-3205(90)90287-2

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The possible role of thromboxane (TX) A2 in mediating the bronchopulmonary effect of endothelin (ET) was studied in isolated guinea pig airways (trachea, upper bronchi and parenchyma). ET (1-100 nM) evoked a concentration-dependent contraction of all three tissues. The contractile response was significantly attenuated by pretreatment of the tissues with the specific thromboxane receptor blockers, BM 13177 (10-50 μM) and BM 13505 (1-5 μM). Furthermore, ET caused a dose-dependent TXB2 release from trachea and parenchyma. These findings suggest that the bronchopulmonary action of ET is mediated, in part, by the release of TXA2. © 1990.

引用

页码：1845 / 1850

页数：6

共 18 条

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