CORTICOTROPIN-RELEASING HORMONE AUGMENTS NATURAL-KILLER-CELL ACTIVITY THROUGH A NALOXONE-SENSITIVE PATHWAY

被引：60

作者：

CARR, DJJ ^{[1
]}

DECOSTA, BR ^{[1
]}

JACOBSON, AE ^{[1
]}

RICE, KC ^{[1
]}

BLALOCK, JE ^{[1
]}

机构：

[1] NIDDK, MED CHEM LAB, BETHESDA, MD 20892 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1990年 / 28卷 / 01期

关键词：

Adrenocorticotropic hormone; Corticotropin-releasing hormone; Endorphin-β; Natural killer cell; Neuroimmunomodulation; Opioid receptor;

D O I：

10.1016/0165-5728(90)90040-T

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Overnight treatment of murine leukocytes with corticotropin-releasing hormone (CRH) and arginine vasopressin enhances natural killer cell activity. Moreover, the opioid receptor antagonist, naloxone, as well as the delta-class opioid receptor antagonist, naltrindole, can block this effect. The responsivity of murine leukocytes to CRH is both dose- and time-dependent. The effector cells are both MAC-1 and Thy-1.2 antigen-positive. Whereas β-endorphin is also shown to enhance natural killer cell activity in a naloxone-reversible manner, adrenocorticotropic hormone (ACTH) has a negligible effect. Macrophage depletion prior to incubation with CRH blocks the CRH-induced natural killer cell augmentation. These results suggest hypothalamic-releasing hormones such as CRH may have a biologically relevant role in the modulation of immune cells either directly or indirectly through the induction of neuropeptide hormones known to have immunomodulatory capabilities. © 1990.

引用

页码：53 / 61

页数：9

共 29 条

[1] MOLECULAR-PROPERTIES OF OPIOID RECEPTORS [J].