A NEW PLASMIDIC CEFOTAXIMASE FROM PATIENTS INFECTED WITH SALMONELLA-TYPHIMURIUM

被引：160

作者：

BAUERNFEIND, A ^{[1
]}

CASELLAS, JM ^{[1
]}

GOLDBERG, M ^{[1
]}

HOLLEY, M ^{[1
]}

JUNGWIRTH, R ^{[1
]}

MANGOLD, P ^{[1
]}

ROHNISCH, T ^{[1
]}

SCHWEIGHART, S ^{[1
]}

WILHELM, R ^{[1
]}

机构：

[1] UNIV CATOLICA ARGENTINA,RA-1227 RIOBAMBA,ARGENTINA

来源：

INFECTION | 1992年 / 20卷 / 03期

关键词：

D O I：

10.1007/BF01704610

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Salmonella typhimurium strains resistant to most beta-lactams, co-trimoxazole, tobramycin and gentamicin were isolated from patients in two hospitals in Buenos Aires, Argentina, beginning in August 1990. The patients were suffering from meningitis, septicaemia or enteritis. Therapy including ampicillin, ceftriaxone and gentamicin failed. The strains produced a plasmidic (pMVP-4) extended broad-spectrum beta-lactamase which is more active against cefotaxime than against ceftazidime (V(max) for cefotaxime 350 times higher than for ceftazidime). This cefotaximase demonstrates similarity to the previously described CTX-ase-M-1 from Escherichia coli, but it is distinctly different from CTX-ase-M-1 by its isoelectric point (7.9 for CTX-ase-M-2 in comparison with 8.9 for CTX-ase-M-1) as well as in its lower susceptibility to the beta-lactamase inhibitors sulbactam, clavulanic acid, tazobactam and BRL 42715. Thus, the beta-lactamase produced by S. typhimurium strains from Argentina appears to represent a new member (CTX-ase-M-2) of a novel group of plasmidic extended broad-spectrum beta-lactamases designated as cefotaximases.

引用

页码：158 / 163

页数：6

共 11 条

[1]

BARTHELEMY M, 1992, IN PRESS BIOCH BIOPH, V1120

[2] A NEW PLASMIDIC CEFOTAXIMASE IN A CLINICAL ISOLATE OF ESCHERICHIA-COLI [J].